博士生導(dǎo)師 碩士生導(dǎo)師

徐甲坤，男，1984年1月生人，于2011年9月獲日本名古屋大學(xué)生物無機(jī)化學(xué)專業(yè)博士學(xué)位，現(xiàn)任中國水產(chǎn)科學(xué)研究院黃海水產(chǎn)研究所研究員，博士研究生導(dǎo)師、博士后合作導(dǎo)師。主要從事生物催化與轉(zhuǎn)化等研究，主持國家自然科學(xué)基金、科技部高端外國專家引智項(xiàng)目、農(nóng)業(yè)農(nóng)村部農(nóng)業(yè)國際交流合作項(xiàng)目、山東省重點(diǎn)研發(fā)計(jì)劃等10余項(xiàng)項(xiàng)目；在ACS Catalysis、Journal of Hazardous Materials、Biosensors and Bioelectronics、Bioresource Technology、Journal of Agriculturaland Food Chemistry、International Journal of Biological Macromolecules、Catalysis Science&Technology、Chemistry–A European Journal等國際知名期刊發(fā)表論文60余篇，其中第一/通訊作者SCI 40余篇；獲授權(quán)國家發(fā)明專利近20項(xiàng)（第一發(fā)明人10項(xiàng)）；主編副主編出版著作4部；入選中國水產(chǎn)科學(xué)研究院“百名英才培育計(jì)劃”、中國水產(chǎn)科學(xué)研究院“青年英才”拔尖人才，榮獲山東省海洋與漁業(yè)科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng)（2025，1/8）和青年科技獎(jiǎng)（2023）、中國水產(chǎn)科學(xué)研究院黃海水產(chǎn)研究所青年科技獎(jiǎng)；擔(dān)任中國水產(chǎn)科學(xué)研究院海洋生物酶工程創(chuàng)新團(tuán)隊(duì)副首席；兼任亞太水產(chǎn)養(yǎng)殖中心網(wǎng)（NACA）技術(shù)指導(dǎo)委員會(huì)委員、中國水產(chǎn)科學(xué)研究院學(xué)術(shù)委員會(huì)委員、中國水產(chǎn)學(xué)會(huì)海水養(yǎng)殖分會(huì)秘書長；擔(dān)任山東大學(xué)、中國海洋大學(xué)、上海海洋大學(xué)、青島科技大學(xué)等高校研究生導(dǎo)師。

聯(lián)系電話：13869828530，0532-85816340

通訊地址：山東省青島市市南區(qū)南京路106號(hào)

郵政編碼：266071

E-mail：xujk@ysfri.ac.cn

代表性文章：

1. Yadan Yang, Xiangmin Meng, Di Yan, Ridong Yang, Feng Liu, Jiakun Xu^*. Structure-guided engineering of P450BM3 as a cofactor-free peroxygenase for efficient biotransformation of cresol pollutants. Bioresour. Technol., 2026, 443, 133834. (JCR1, IF9.0)

2. Ridong Yang, Osami Shoji, Yingwu Lin, Fang Wang, Hongxia Che, Jiakun Xu^*. Construction of P450 scaffold biocatalysts for the biodegradation of five chloroanilines， J. Hazard. Mater., 2025, 488, 137305. (JCR1, IF11.3)

3.Mengyao Chen, Jia Song, Fang Wang, Jiahao Tan, Huaying Zou, Jiakun Xu^*. Cloning, expression and characterization of glutathione S-transferase from Euphausia superba. J. Agric. Food Chem., 2025, 73, 30183–30195. (JCR1, IF6.2)

4. Sijia Zhao, Yingwu Lin, Jinghan Wang, Dong Li, Fang Wang, Osami Shoji, Jiakun Xu^*. Regioselective aromatic O-demethylation with an artificial P450BM3/sugar alcohol oxidase peroxygenase system, Int. J. Biol. Macromol., 2025, 309, 142768.(JCR1, IF8.5)

5. Jiahao Tan, Huaying Zou, Jun Sheng , Dong Li, Fang Wang, Jiakun Xu^*. Cloning, expression and characterization of xylose isomerase from Euphausia superba, Int. J. Biol. Macromol., 2025, 322, 146782. (JCR1, IF8.5)

6. Weikang Zhang, Yadan Yang, Xiangmin Meng,*, Fang Wang, Yingwu Lin*, Jiakun Xu^*. Construction of artificial peroxidase based on myoglobin scaffold for efficient degradation of meloxicam, J. Inorg. Biochem., 2025, 262, 112733. (JCR1, IF3.2)

7. Yadan Yang, Weikang Zhang, Fang Wang, Dong Li, Xiangmin Meng, Xiaochun Sun, Jiakun Xu^*. Construction of biocatalysts based on P450BM3 for the degradation of non-steroidal anti-inflammatory drugs, J. Hazard. Mater., 2024, 480, 136097.(JCR1, IF12.2)

8. Weikang Zhang, Yingwu Lin, Xiangmin Meng, Qiaoning Wang, Lingxin Chen*, Jiakun Xu^*. Construction of a myoglobin scaffold-based biocatalyst for the biodegradation of sulfadiazine and sulfathiazole, J. Hazard. Mater., 2024, 465, 113147.(JCR1, IF12.2)

9. Guangrong Wu, Jiakun Xu^*, Lijuan Sun, Yingfu Li, Shuqin Gao, Yingwu Lin^*. Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants, J. Environ. Chem. Eng., 2023, 11, 111471. (JCR1, IF7.4)

10. Bin Qiao^*, Jiakun Xu^*, Wenhao Yin, Wanmeng Xin, Lixin Ma, Jie Qiao^*, Yi Liu^*. “Aptamer-locker” DNA coupling with CRISPR/Cas12a-guided biosensing for high-efficiency melamine analysis, Biosens. Bioelectron., 2021, 183, 113233.(JCR1, IF12.545)

11. Yihui Jiang, Chunlan Wang, Nana Ma, Jie Chen, Chuanfei Liu, Fang Wang, Jiakun Xu^*, Zhiqi Cong^*. Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system, Catal. Sci. Technol., 2020, 10, 1219-1223.(JCR1, IF6.119)

12. Jiakun Xu, Chunlan Wang, Zhiqi Cong^*. Strategies for substrate-regulated p450 catalysis: from substrate engineering to co-catalysis, Chem. Eur. J., 2019, 25, 6853-6863.(JCR1, IF5.16)

代表性發(fā)明專利：

1. 一種南極磷蝦來源的谷胱甘肽S-轉(zhuǎn)移酶及其編碼基因與應(yīng)用（ZL 202510876088.1，1/4）

2. 一種南極磷蝦來源的胰蛋白酶、編碼基因及其降解塑化劑的應(yīng)用（ZL 202510107772.3，1/4）

3. 一種南極磷蝦來源木糖異構(gòu)酶及其突變體和應(yīng)用（ZL 202411513932.6，1/4）

4. 一種催化木質(zhì)素芳香醚單體O-脫甲基化的突變體及其應(yīng)用（ZL 202411287684.8，1/3）

5. 一種催化合成吩嗪和吩噁嗪酮類化合物的突變體及其應(yīng)用（ZL 202410897942.8，1/4）

6. 一種基于細(xì)胞色素P450BM3的突變體、制劑及其降解非甾體抗炎藥的應(yīng)用（ZL 202411178066.X，1/4）

7. 脫乙酰酶及其編碼基因、重組質(zhì)粒、重組菌與應(yīng)用（ZL 202311640396.1，1/5）

8. 抹香鯨Mb及突變體H64D/V68I Mb在降解磺胺類化合物中的應(yīng)用（ZL 202310229633.9，1/3）