王洪巖，1989年出生，中國水產(chǎn)科學(xué)研究院黃海水產(chǎn)研究所助理研究員，2019年獲武漢大學(xué)生物化學(xué)與分子生物學(xué)博士學(xué)位。主要研究方向：利用基因組學(xué)、單細(xì)胞轉(zhuǎn)錄組學(xué)和表觀遺傳組學(xué)等高通量技術(shù)手段，聚焦海水養(yǎng)殖物種免疫系統(tǒng)構(gòu)成和抗病抗逆的分子機(jī)制研究，探索免疫系統(tǒng)的功能演化，發(fā)掘新的免疫防御機(jī)制，并研究免疫與生長和代謝之間的關(guān)系。承擔(dān)國家自然科學(xué)基金項(xiàng)目1項(xiàng)，山東省博士后創(chuàng)新項(xiàng)目資助1項(xiàng)。目前在Science Advances，Cell Host & Microbe等雜志發(fā)表論文10余篇，其中第一作者2篇。
代表性論文
1. Li W,Wang HY, Zhao X, Duan H, Cheng B, Liu Y, Zhao M, Shu W, Mei Y, Wen Z, Tang M, Guo L, Li G, Chen Q, Liu X, Du HN. A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair.Sci Adv. 2019 Mar 6;5(3):eaau7566.
2. Wang HY, Li Y, Xue T, Cheng N, Du HN. Construction of a series of pCS2+ backbone-based Gateway vectors for overexpressing various tagged proteins in vertebrates.Acta Biochim Biophys Sin (Shanghai). 2016 Dec;48(12):1128-1134.
3. Liu X, Huang Y, Tan F,Wang HY, Chen JY, Zhang X, Zhao X, Liu K, Wang Q, Liu S, Piferrer F, Fan G, Shao C. Single-Cell Atlas of the Chinese Tongue Sole (Cynoglossus semilaevis) Ovary Reveals Transcriptional Programs of Oogenesis in Fish.Front Cell Dev Biol. 2022 Mar 1;10:828124.
4. Lu YF, Liu Q, Liu KQ,Wang HY, Li CH, Wang Q, Shao CW. Identification of global alternative splicing and sex-specific splicing via comparative transcriptome analysis of gonads of Chinese tongue sole (Cynoglossus semilaevis).Zool Res. 2022 May 18;43(3):319-330.
5. Lu B, Ren Y, Sun X, Han C,Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B, Huang Z. Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3.Cell Host Microbe. 2017 Jul 12;22(1):86-98.e4.
6. Li WZ,Wang HY, Du HN. Research Progress on Non-histone Protein Methylation.Progress in Biochemistry and Biophysics. 2015, 42(11): 1015-1025.
